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1 month, 2 weeks ago

what is Hfr cell

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P Priyanka Kumari
Answered 1 month ago

HFR cell is a high-frequency recombination cell. It is a bacterium with a conjugative plasmid integrated into its chromosomal DNA. The integration of the plasmid into the cell's chromosome is through homologous recombination. A conjugative plasmid capable of chromosome integration is also called an episome (a segment of DNA that can exist as a plasmid or become integrated into the chromosome). When conjugation occurs, Hfr cells are very efficient in delivering chromosomal genes of the cell into recipient F− cells, which lack the episome.

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